Sneha J.

Subject matter expert in precision medicine

• Scientific data management: o Analysis and Clinical reporting of Diagnostic, Prognostic and Therapeutic associations of genomic biomarkers in somatic cancers in various aspects like, Gene summaries, Disease ontologies, Drug Databases, Variant databases (ClinVar, COSMIC, TP53 database), Oncology databases (OncoKb, Mycancergenome, PharmGKb, CIVIC), collectively for Variant classifications (CAP/AMP/ASCO classification, FDA Evidence level, etc) using Drug labels, Companion diagnostic tests, Clinical practice guidelines, Scientific publications and Clinical trials. o Literature analysis for competitive intelligence using Thomson Reuters, Bioinfobank, clinicaltrials.gov, FDA, PubMed, etc. Compilation of literature data and presentation of analyzed data in project meetings. • Experimentation: o In vivo Experiments: Evaluation of pharmacodynamic activities of new chemical compounds (more than 400) in relevant animal models for various drug targets. Consideration of physicochemical properties and pharmacokinetic data for selection of dose regimen.